DNA interpolyelectrolyte complexes as a tool for efficient cell transformation.

@article{Kabanov1991DNAIC,
  title={DNA interpolyelectrolyte complexes as a tool for efficient cell transformation.},
  author={Alexander V Kabanov and I V Astafyeva and Michael L Chikindas and Gennady Rosenblat and Vladimir Kiselev and Evgenii S. Severin and Victor A. Kabanov},
  journal={Biopolymers},
  year={1991},
  volume={31 12},
  pages={
          1437-43
        }
}
A tool was developed for enhancement of plasmid penetration into an intact cell, based on increasing DNA hydrophobicity via inclusion into a soluble interpolyelectrolyte complex (IPC) with polycations. The characteristics of formation of DNA IPC with synthetic polycations [poly(N-ethyl-4-vinylpyridinium)bromide (PVP) and PVP modified with 3% of N-cetyl-4-vinylpyridinium units (PVP-C)] were studied using ultracentrifugation and polyacrylamide gel electrophoresis methods. The conditions were… CONTINUE READING
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