DNA interchain cross-links formed by acrolein and crotonaldehyde.

  title={DNA interchain cross-links formed by acrolein and crotonaldehyde.},
  author={Ivan D. Kozekov and Lubomir V Nechev and M Scott Moseley and Constance M. Harris and Carmelo J. Rizzo and Michael P Stone and Thomas M. Harris},
  journal={Journal of the American Chemical Society},
  volume={125 1},
Acrolein and higher alpha,beta-unsaturated aldehydes are bifunctional genotoxins. The deoxyguanosine adduct of acrolein, 3-(2-deoxy-beta-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a]purin-10(3H)-one (8-hydroxy-1,N(2)-propanodeoxyguanosine, 2a), is a major DNA adduct formed by acrolein. The potential for oligodeoxynucleotide duplexes containing 2a to form interchain cross-links was evaluated by HPLC, CZE, MALDI-TOF, and melting phenomena. Interchain cross-links represent… CONTINUE READING