DNA interaction of new copper(II) complexes with sulfonamides as ligands.


New copper(II) complexes with sulfonamide ligands have been prepared and characterized. Sulfonamide ligands were prepared through a reaction between 8-aminoquinoline and either 2-mesitylene (Hqmesa), 4-tert-butylbenzene (Hqtbsa), or alpha-toluene (Halphaqtsa) sulfonyl chlorides. The structural analysis carried out for complex [Cu(alphaqtsa)(2)] indicated that the local environment of the Cu(II) cation is between a square planar and a tetrahedral geometry, with stacking of the benzene rings of the sulfonyl ligands between neighbor molecules. Powder EPR spectra at room temperature gave rhombic spectra for the [Cu(alphaqtsa)(2)] and [Cu(qmesa)(2)] complexes and an axial spectrum for the [Cu(qtbsa)(2)] complex, probably due to the steric hindrance of the methyl groups. Complexes [Cu(alphaqtsa)(2)] and [Cu(qmesa)(2)] are artificial chemical nucleases that degrade DNA in the presence of sodium ascorbate. A study of the radical scavengers revealed that the ROS (reactive oxygen species) involved in the DNA damage were hydroxyl, singlet oxygen-like species, and superoxide anion.

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@article{Macas2007DNAIO, title={DNA interaction of new copper(II) complexes with sulfonamides as ligands.}, author={Benigno Mac{\'i}as and Mar{\'i}a Virginia Villa and Beatriz L. G{\'o}mez and J. Fern{\'a}ndez- Borr{\'a}s and Gloria Alzuet and Marta Gonz{\'a}lez-{\'A}lvarez and Alfonso Casti{\~n}eiras}, journal={Journal of inorganic biochemistry}, year={2007}, volume={101 3}, pages={444-51} }