DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage

@inproceedings{Chaux2007DNAII,
  title={DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage},
  author={Nicole de la Chaux and Philipp W. Messer and Peter F. Arndt},
  booktitle={BMC Evolutionary Biology},
  year={2007}
}
Insertions and deletions of DNA segments (indels) are together with substitutions the major mutational processes that generate genetic variation. Here we focus on recent DNA insertions and deletions in protein coding regions of the human genome to investigate selective constraints on indels in protein evolution. Frequencies of inserted and deleted amino acids differ from background amino acid frequencies in the human proteome. Small amino acids are overrepresented, while hydrophobic, aliphatic… CONTINUE READING

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