DNA in a material world

  title={DNA in a material world},
  author={Nadrian C. Seeman},
  • N. Seeman
  • Published 23 January 2003
  • Biology
  • Nature
The specific bonding of DNA base pairs provides the chemical foundation for genetics. This powerful molecular recognition system can be used in nanotechnology to direct the assembly of highly structured materials with specific nanoscale features, as well as in DNA computation to process complex information. The exploitation of DNA for material purposes presents a new chapter in the history of the molecule. 
DNA-programmed assembly of nanostructures.
The emerging field of DNA-nanotechnology is now exploring DNA-programmed processes for the assembly of organic compounds, biomolecules, and inorganic materials.
In the field of structural DNA nanotechnology, researchers create artificial DNA sequences to self-assemble into target molecular superstructures and nanostructures. The well-understood Watson–Crick
Nanostructures on a Vector : Enzymatic Oligo Production for DNA Nanotechnology
The technique of DNA origami utilizes the specific and limited bonding properties of DNA to fold single stranded DNA sequences of various lengths to form a predesigned structure. One longer sequenc
Functional evolution on the assembled DNA template.
This tutorial review attempts to present an overview of the applications of DNA templates, including its biological significance, the directing of chemical reactions at the molecular level, as well as the placing of nanoparticles and proteins in position.
The use of enzymes for construction of DNA-based objects and assemblies.
An overview of the enzyme-catalysed construction of DNA-based objects and assemblies is presented and it is illustrated how a diversity of enzyme-based biochemical reactions are transferred in nanotechnological applications.
Functional Materials Derived from DNA
DNA has special properties and its unique double-helical structure offers excellent prospects forcreating novel DNA-based materials. In recent years, DNA has been shown to be an ideal molecule in
Assembling Materials with DNA as the Guide
DNA's remarkable molecular recognition properties and structural features make it one of the most promising templates to pattern materials with nanoscale precision, and it can be used to precisely position proteins, nanoparticles, transition metals, and other functional components into deliberately designed patterns.


Electronic properties of DNA
Experiments are now starting to provide the first clues about the mechanisms that underlie charge transport in DNA.
A DNA-fuelled molecular machine made of DNA
The construction of a DNA machine in which the DNA is used not only as a structural material, but also as ‘fuel’; each cycle produces a duplex DNA waste product.
Twisting and stretching single DNA molecules.
DNA Handles for Single Molecule Experiments
A procedure for covalent binding of DNA to polystyrene microspheres for optical tweezers experiments in aqueous buffer solutions is worked out and DNA handles were attached to proteins to enable future probing of individual single proteins.
Design and self-assembly of two-dimensional DNA crystals
The design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules that create specific periodic patterns on the nanometre scale are reported.
Mechanical separation of the complementary strands of DNA.
The separation force signal is shown to be related to the local GC vs. AT content along the molecule, and variations of this content on a typical scale of 100-500 bases are presently detected.
Nucleic Acid Nanostructures and Topology.
The assembly of two-dimensional crystals with programmed topographic characteristics demonstrates the simplicity of translating design into surface structures.
DNA: An Extensible Molecule
The force-displacement response of a single duplex DNA molecule was measured and a highly cooperative transition to a state here termed S-DNA is revealed, which yields a force plateau and suggests a structure for the extended form.
A nanomechanical device based on the B–Z transition of DNA
This work has constructed a supramolecular device consisting of two rigid DNA ‘double-crossover’ (DX) molecules connected by 4.5 double-helical turns, using the transition between the B and Z, forms of DNA to effect switchable motion.
Synthesis from DNA of a molecule with the connectivity of a cube
This work reports the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices, the first construction of a closed polyhedral object from DNA.