DNA immunization is associated with increased activity of type I iodothyronine 5'-deiodinase in mouse liver.

@article{Brtko1999DNAII,
  title={DNA immunization is associated with increased activity of type I iodothyronine 5'-deiodinase in mouse liver.},
  author={J{\'u}lius Brtko and Sven Mostb{\"o}ck and Sandra Scheiblhofer and Andrea Hartl and Josef Thalhamer},
  journal={Molecular and cellular endocrinology},
  year={1999},
  volume={152 1-2},
  pages={85-9}
}
Inflammatory cytokines in vitro are believed to be involved in the regulation of type I iodothyronine 5'-deiodinase (5'-DI) activity. The present study was undertaken to investigate in vivo effects of DNA immunization of mice on the 5'-DI activity in the liver. A mammalian expression vector encoding the beta-galactosidase (pCMV-betagal) was used for intradermal immunization. Furthermore, immunostimulatory CpG motifs, which induce the expression of IL-6, IL-12, IL-18, TNF-alpha/beta and IFN… CONTINUE READING