DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.

@article{Nohesara2011DNAHO,
  title={DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.},
  author={Shabnam Nohesara and Mohammad Ghadirivasfi and Sahar Mostafavi and Mohammad-Reza Eskandari and Hamidreza Ahmadkhaniha and Sam Thiagalingam and Hamid Mostafavi Abdolmaleky},
  journal={Journal of psychiatric research},
  year={2011},
  volume={45 11},
  pages={1432-8}
}
The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 115 human post-mortem brain samples from the frontal lobe and reported DNA hypo methylation of the membrane-bound catechol-O-methyltransferase (MB-COMT) gene promoter, associated… CONTINUE READING

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