DNA hypomethylation in cancer cells.

@article{Ehrlich2009DNAHI,
  title={DNA hypomethylation in cancer cells.},
  author={M. Ehrlich},
  journal={Epigenomics},
  year={2009},
  volume={1 2},
  pages={
          239-59
        }
}
  • M. Ehrlich
  • Published 2009
  • Biology, Medicine
  • Epigenomics
DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors. However, for several decades after its independent discovery by two laboratories in 1983, it was often ignored as an unwelcome complication, with almost all of the attention on the hypermethylation of promoters of genes that are silenced in cancers (e.g., tumor-suppressor genes). Because it was subsequently shown that global hypomethylation of DNA in cancer was most closely associated with repeated DNA… Expand
655 Citations

Paper Mentions

Interventional Clinical Trial
Multicenter Phase II study on Decitabine-Carboplatin combination in platinum resistant ovarian cancer patients. Patients will receive study treatment until disease progression is… Expand
ConditionsRecurrent, Platinum-resistant Ovarian Cancer
InterventionDrug
DNA hypomethylation and hemimethylation in cancer.
  • 102
Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies.
  • 12
DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey
  • 82
  • PDF
The Importance of Aberrant DNA Methylation in Cancer
  • 3
  • PDF
DNA Methylation and Cancer
  • 1
Non-canonical aberrant DNA hypermethylation in glioma
  • PDF
Global DNA hypomethylation coupled to cellular transformation and metastatic ability
  • 7
Hypomethylation of repeated DNA sequences in cancer.
  • 84
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 258 REFERENCES
Cancer-linked DNA hypomethylation and its relationship to hypermethylation.
  • M. Ehrlich
  • Biology, Medicine
  • Current topics in microbiology and immunology
  • 2006
  • 130
DNA methylation in cancer: too much, but also too little
  • 1,341
  • PDF
Causes and consequences of DNA hypomethylation in human cancer.
  • M. Hoffmann, W. Schulz
  • Biology, Medicine
  • Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2005
  • 225
A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others
  • 45
DNA methylation and cancer.
  • P. Das, R. Singal
  • Medicine, Biology
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
  • 839
  • PDF
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
  • 253
  • PDF
...
1
2
3
4
5
...