DNA hypomethylation in cancer cells.

  title={DNA hypomethylation in cancer cells.},
  author={M. Ehrlich},
  volume={1 2},
DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors. However, for several decades after its independent discovery by two laboratories in 1983, it was often ignored as an unwelcome complication, with almost all of the attention on the hypermethylation of promoters of genes that are silenced in cancers (e.g., tumor-suppressor genes). Because it was subsequently shown that global hypomethylation of DNA in cancer was most closely associated with repeated DNA… CONTINUE READING