DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.

  title={DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.},
  author={Tao Fan and Anja Schmidtmann and Sichuan Xi and Victorino Briones and Heming Zhu and Hyung Chan Suh and John M. Gooya and Jonathan R. Keller and Hong Xu and Jean A. Roayaei and Miriam Anver and Sandra K. Ruscetti and Kathrin Muegge},
  volume={3 3},
Hematopoietic malignancies are frequently associated with DNA hypomethylation but the molecular mechanisms involved in tumor formation remain poorly understood. Here we report that mice lacking Lsh develop leukemia associated with DNA hypomethylation and oncogene activation. Lsh is a member of the SNF2 chromatin remodeling family and is required for de novo methylation of genomic DNA. Mice that received Lsh deficient hematopoietic progenitors showed severe impairment of hematopoiesis… CONTINUE READING


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