DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type.

  title={DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type.},
  author={Stephen E Hawes and Joshua E. Stern and Qinghua Feng and Linda W. Wiens and Janet S. Rasey and Hiep Lu and Nancy B. Kiviat and Hubert Vesselle},
  journal={Lung cancer},
  volume={69 2},
BACKGROUND We previously identified a number of genes which were methylated significantly more frequently in the tumor compared to the non-cancerous lung tissues from non-small cell lung cancer (NSCLC) patients. Detection of methylation profiles of genes in NSCLC could provide insight into differential pathways to malignancy and lead to strategies for better treatment of individuals with NSCLC. METHODS We determined the DNA methylation status of 27 genes using quantitative MethyLight assays… CONTINUE READING
28 Citations
55 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 55 references

MGMT methylation in diffuse large B - cell lymphoma : validation of quantitativemethylationspecific PCR and comparisonwithMGMT protein expression

  • J Storey
  • J Clin Pathol
  • 2009

Quanti - tative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors

  • L Ries, D Melbert, D Stinchcomb, N Howlader
  • Cancer Res
  • 2009

Application of a methylation gene panel by quantitative PCR for lung cancers

  • DS Shames, JD Minna, AF Gazdar
  • Cancer Lett
  • 2007

Flu - orodeoxyglucose uptake of primary non - small cell lung cancer at positron emission tomography : new contrary data on prognostic role

  • H Vesselle, J Grierson, M Muzi, JM Pugsley, RA Schmidt, P Rabinowitz
  • Clin Cancer Res
  • 2007

Methods for detecting DNA methylation in tumors : from bench to bedside

  • H Vesselle, JD Freeman, L Wiens, J Stern, HQ Nguyen, SE Hawes
  • Cancer Lett
  • 2007

Promoter hypermethylation of RASSF 1 A and RUNX 3 genes as an independent prognostic predictionmarker in surgically resectednonsmall

  • A Virmani, A Rathi, S Heda, K Sugio, C Lewis, V Tonk
  • cell lung cancers Lung Cancer
  • 2007

Similar Papers

Loading similar papers…