DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis.

@article{Wang2014DNAHO,
  title={DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis.},
  author={Y Y Wang and Qian Wang and Xing Huai Sun and Richard Z. Liu and Yanwen Shu and Takuro Kanekura and Ji Hong Huang and Yi Li and James Chun-Huan Wang and Mingming Zhao and Qiu Lu and Rong Xiao},
  journal={The British journal of dermatology},
  year={2014},
  volume={171 1},
  pages={39-47}
}
BACKGROUND Systemic sclerosis (SSc) is a complex autoimmune disease that involves dysregulation of immune homeostasis. The failure of impaired regulatory T cells (Tregs) to maintain immune homeostasis plays a major role in the development of SSc. Transcriptional silencing of the forkhead box protein 3 gene (FOXP3) via hypermethylation of regulatory regions has been identified as a hallmark of committed Tregs and several autoimmune disorders. OBJECTIVES To investigate whether aberrant… CONTINUE READING
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