DNA hypermethylation in breast cancer and its association with clinicopathological features.

@article{Li2006DNAHI,
  title={DNA hypermethylation in breast cancer and its association with clinicopathological features.},
  author={Shaoying Li and Minna Rong and Barry Iacopetta},
  journal={Cancer letters},
  year={2006},
  volume={237 2},
  pages={272-80}
}
Aberrant hypermethylation of gene promoter regions is one of the mechanisms for inactivation of tumour suppressor genes in breast cancer. We investigated whether hypermethylation identifies breast cancers with distinctive clinical and pathological features. We evaluated the methylation of RARbeta2, CDH1, ER, BRCA1, CCND2, p16 and TWIST in 193 breast carcinomas. Methylation frequencies ranged from 11% for CCND2 to 84% for ER. Tumours with frequent methylation (4-6 genes) were more often poorly… CONTINUE READING