DNA hypermethylation as an epigenetic mark for oral cancer diagnosis.

  title={DNA hypermethylation as an epigenetic mark for oral cancer diagnosis.},
  author={Raghu Radhakrishnan and Shamaprasad Kabekkodu and Kapaettu Satyamoorthy},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={40 9},
Oral cancer is the largest group of cancers which fall into the head and neck category. While genetic alterations in oral cancer have long been documented, the effect of epigenetic changes is more recent. The recent explosion in science of how chromatin organization modulates the gene expression has highlighted the epigenetic mechanism of oral cancer pathogenesis. DNA methylation, which is an important epigenetic marker, is perhaps the best characterized chemical modification of mammalian DNA… CONTINUE READING
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Tumorspecific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence

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  • Clin Cancer Res
  • 2007
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