DNA-helix bending, stiffening and elongation on ligand binding; analysis for several DNA-drug systems, general viscometric DNA response and stereochemical implications.

@article{Reinert1991DNAhelixBS,
  title={DNA-helix bending, stiffening and elongation on ligand binding; analysis for several DNA-drug systems, general viscometric DNA response and stereochemical implications.},
  author={Katrin Reinert},
  journal={Journal of biomolecular structure & dynamics},
  year={1991},
  volume={9 2},
  pages={331-52}
}
  • Katrin Reinert
  • Published 1991 in Journal of biomolecular structure & dynamics
For several DNA-ligand systems the DNA helix bending, stiffening and elongation behaviour is treated quantitatively. The experimental basis are viscosity data from literature as a function of r, the ratio of drug molecules bound per DNA monomer unit. If the relative viscosity changes delta y1(r) and delta yh(r) for DNA of low and high molar mass, respectively, are known, the relative changes of contour length, delta L/L degrees, and of persistence length, delta a/a degrees, can be evaluated as… CONTINUE READING