DNA helix: the importance of being GC-rich.

  title={DNA helix: the importance of being GC-rich.},
  author={Alexander E. Vinogradov},
  journal={Nucleic acids research},
  volume={31 7},
A new explanation for the emergence of heavy (GC-rich) isochores is proposed, based on the study of thermostability, bendability, ability to B-Z transition and curvature of the DNA helix. The absolute values of thermostability, bendability and ability to B-Z transition correlated positively with GC content, whereas curvature correlated negatively. The relative values of these parameters were determined as compared to randomized sequences. In genes and intergenic spacers of warm-blooded animals… CONTINUE READING

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