DNA helical stability accounts for mutational defects in a yeast replication origin.

@article{Natale1992DNAHS,
  title={DNA helical stability accounts for mutational defects in a yeast replication origin.},
  author={Darren A. Natale and Andrea Schubert and David Kowalski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 7},
  pages={2654-8}
}
Earlier studies on the H4 autonomously replicating sequence (ARS) identified a DNA unwinding element (DUE), a required sequence that is hypersensitive to single-strand-specific nucleases and serves to facilitate origin unwinding. Here we demonstrate that a DUE can be identified in the C2G1 ARS, a chromosomal replication origin, by using a computer program that calculates DNA helical stability from the base sequence. The helical stability minima correctly predict the location and hierarchy of… CONTINUE READING
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