DNA helical instability facilitates initiation at the SV40 replication origin.

@article{Lin1994DNAHI,
  title={DNA helical instability facilitates initiation at the SV40 replication origin.},
  author={Songnian Lin and David Kowalski},
  journal={Journal of molecular biology},
  year={1994},
  volume={235 2},
  pages={496-507}
}
Previous analysis of mutations in bacterial and yeast replication origins has identified a genetic component, termed a DNA unwinding element (DUE), whose intrinsic helical instability is essential for origin function. For the SV40 replication origin, we show here that the early palindrome (EP) and A + T-rich (AT) domains both exhibit helical instability, despite their dissimilar A + T compositions. To test the possible contribution of helical instability to SV40 origin function, the… CONTINUE READING

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