DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.

@article{Sreedharan1990DNAGG,
  title={DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.},
  author={Sunil Sreedharan and Mike W. Oram and B. U. Jensen and Lance R. Peterson and Linda M. Fisher},
  journal={Journal of bacteriology},
  year={1990},
  volume={172 12},
  pages={7260-2}
}
The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine----leucine) and/or codon 85 (serine----proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83----leucine and alanine 84----proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in… CONTINUE READING

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References

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Showing 1-10 of 19 references

Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureus

J. S. Wolfson, D. C. Hooper
Antimicrob . Agents Chemother . • 1989

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