DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage.

@article{Smith2007DNAGH,
  title={DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage.},
  author={Ian M. Smith and Wojciech Mydlarz and Suhail Kamrudin Mithani and Joseph A. Califano},
  journal={International journal of cancer},
  year={2007},
  volume={121 8},
  pages={1724-8}
}
Epigenetic changes have been implicated in the pathogenesis of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Prior efforts have primarily examined regional promoter hypermethylation as a silencer of tumor suppressor gene expression. To analyze the global state of methylation in the HNSCC genome, we utilize pyrosequencing of repetitive elements (LINEs) to compare the state of global methylation in HNSCC to normal aerodigestive mucosa. 137 samples (119 HNSCC tumors and 18… CONTINUE READING

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