DNA-functionalized nanotube membranes with single-base mismatch selectivity.

  title={DNA-functionalized nanotube membranes with single-base mismatch selectivity.},
  author={Punit Kohli and Chad C. Harrell and Zehui Cao and Rahela Gasparac and Weihong Tan and Charles R. Martin},
  volume={305 5686},
We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a "transporter" DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands… CONTINUE READING


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