DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples

@article{Pandey2016DNAFD,
  title={DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples},
  author={U. Pandey and A. Bell and Daniel W Renner and D. A. Kennedy and Jacob Shreve and Chris L. Cairns and Matthew J. Jones and P. Dunn and A. Read and M. Szpara},
  journal={mSphere},
  year={2016},
  volume={1}
}
Despite both clinical and laboratory data that show increased virulence in field isolates of MDV-1 over the last half century, we do not yet understand the genetic basis of its pathogenicity. Our knowledge of genome-wide variation between strains of this virus comes exclusively from isolates that have been cultured in the laboratory. MDV-1 isolates tend to lose virulence during repeated cycles of replication in the laboratory, raising concerns about the ability of cultured isolates to… Expand
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