DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

@article{Yamamoto1992DNAFB,
  title={DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth},
  author={Saburo Yamamoto and Toshiko Yamamoto and Shizuo Shimada and Etsuro Kuramoto and Osamu Yano and Tetsuro Kataoka and Tohru Tokunaga},
  journal={Microbiology and Immunology},
  year={1992},
  volume={36}
}
The nucleic acid fraction from cells of 6 species of bacterium and 2 kinds of vertebrate, calf and salmon, was extracted and purified by the same procedures as described previously. When the spleen cells from BALB/c mice were incubated with the nucleic acid fraction from either of the bacteria, natural killer (NK) activity of the cells was remarkably elevated and the cells produced factors to activate macrophages and to inhibit viral growth. It was shown that the factor to activate macrophages… 
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