DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat.

@article{Petito1997DNAFF,
  title={DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat.},
  author={Carol K. Petito and Jorge Antonio Torres-Mu{\~n}oz and B G Roberts and J P Olarte and Thaddeus S. Nowak and William A Pulsinelli},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1997},
  volume={17 9},
  pages={967-76}
}
Apoptosis is an active, gene-directed process of cell death in which early fragmentation of nuclear DNA precedes morphological changes in the nucleus and, later, in the cytoplasm. In ischemia, biochemical studies have detected oligonucleosomes of apoptosis whereas sequential morphological studies show changes consistent with necrosis rather than apoptosis. To resolve this apparent discrepancy, we subjected rats to 10 minutes of transient forebrain ischemia followed by 1 to 14 days of… CONTINUE READING
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