DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels.

@article{Foquet2002DNAFS,
  title={DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels.},
  author={Mathieu Foquet and Jonas Korlach and Warren R. Zipfel and Watt W. Webb and Harold G. Craighead},
  journal={Analytical chemistry},
  year={2002},
  volume={74 6},
  pages={1415-22}
}
The fabrication of fluidic channels with dimensions smaller than 1 microm is described and characterized in respect to their use for detection of individual DNA molecules. The sacrificial layer technique is used to fabricate these devices as it provides CMOS-compatible materials exhibiting low fluorescence background. It also allows creating microfluidics circuitry of submicrometer dimensions with great control. The small dimensions facilitate single molecule detection and minimize events of… CONTINUE READING

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