DNA fragility in the parallel evolution of pelvic reduction in stickleback fish

@article{Xie2019DNAFI,
  title={DNA fragility in the parallel evolution of pelvic reduction in stickleback fish},
  author={Kathleen T Xie and Guliang Wang and Abbey C Thompson and Julia I Wucherpfennig and Thomas Edward Reimchen and Andrew D C MacColl and Dolph Schluter and Michael A Bell and Karen M Vasquez and David M Kingsley},
  journal={Science},
  year={2019},
  volume={363},
  pages={81-84}
}
Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (Gasterosteus aculeatus). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the Pitx1 gene. Here, we identify molecular features contributing to these recurrent deletions. Pitx1 enhancer sequences form alternative DNA structures in vitro and… CONTINUE READING

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