DNA flow cytometry and pathologic grading as prognostic guides in axillary lymph node-negative breast cancer.

@article{Merkel1993DNAFC,
  title={DNA flow cytometry and pathologic grading as prognostic guides in axillary lymph node-negative breast cancer.},
  author={Douglas E Merkel and David J. Winchester and Robert A. Goldschmidt and Carey Z August and D M Wruck and Alfred W. Rademaker},
  journal={Cancer},
  year={1993},
  volume={72 6},
  pages={1926-32}
}
BACKGROUND The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this association could not be tested for independence from the established prognostic factors of histologic and nuclear grading. METHODS Histologic, nuclear, and mitotic grades, DNA… CONTINUE READING