DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain.

@article{Smith2015DNAEF,
  title={DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain.},
  author={Alicia K. Smith and Varun Kilaru and Torsten Klengel and Kristina B. Mercer and Bekh Bradley and Karen N. Conneely and Kerry J. Ressler and Elisabeth B. Binder},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2015},
  volume={168B 1},
  pages={36-44}
}
DNA methylation has become increasingly recognized in the etiology of psychiatric disorders. Because brain tissue is not accessible in living humans, epigenetic studies are most often conducted in blood. Saliva is often collected for genotyping studies but is rarely used to examine DNA methylation because the proportion of epithelial cells and leukocytes varies extensively between individuals. The goal of this study was to evaluate whether saliva DNA is informative for studies of psychiatric… CONTINUE READING

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