DNA enzyme ED5 depletes egr-1 and inhibits neointimal hyperplasia in rats.

@article{Wang2013DNAEE,
  title={DNA enzyme ED5 depletes egr-1 and inhibits neointimal hyperplasia in rats.},
  author={Tai-Ran Wang and Guang Yang and Gui-nan Liu},
  journal={Cardiology},
  year={2013},
  volume={125 3},
  pages={192-200}
}
OBJECTIVES Depletion of early growth response factor-1 (Egr-1) by a DNA enzyme, ED5, inhibits neointimal hyperplasia (NH) following vascular injury by an unknown mechanism. The aim of this study was to characterize the effects of ED5 in a rat carotid injury model in order to elucidate the mechanism by which ED5 inhibits NH. METHODS ED5 was transfected into the arterial wall of Wistar rats using FuGENE6 transfection reagent following artery balloon injury. Hematoxylin and eosin staining… CONTINUE READING