DNA ends alter the molecular composition and localization of Ku multicomponent complexes.

@article{Adelmant2012DNAEA,
  title={DNA ends alter the molecular composition and localization of Ku multicomponent complexes.},
  author={Guillaume O. Adelmant and Anne S. Calkins and Brijesh K. Garg and Joseph D. Card and Manor Askenazi and Alex Miron and Bijan Sobhian and Yi Zheng Zhang and Yoshihiro Nakatani and Pamela A. Silver and James Dirk Iglehart and Jarrod A. Marto and J S L{\'a}zaro},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 8},
  pages={411-21}
}
The Ku heterodimer plays an essential role in non-homologous end-joining and other cellular processes including transcription, telomere maintenance and apoptosis. While the function of Ku is regulated through its association with other proteins and nucleic acids, the specific composition of these macromolecular complexes and their dynamic response to endogenous and exogenous cellular stimuli are not well understood. Here we use quantitative proteomics to define the composition of Ku… CONTINUE READING