DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

@article{Jager2002DNAES,
  title={DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.},
  author={Martijn de Jager and C. Wyman and Dik C van Gent and Roland Kanaar},
  journal={Nucleic acids research},
  year={2002},
  volume={30 20},
  pages={4425-31}
}
The Rad50, Mre11 and Nbs1 complex is involved in many essential chromosomal organization processes dealing with DNA ends, including two major pathways of DNA double-strand break repair, homologous recombination and non-homologous end joining. Previous data on the structure of the human Rad50 and Mre11 (R/M) complex suggest that a common role for the protein complex in these processes is to provide a physical link between DNA ends such that they can be processed in an organized and coordinated… CONTINUE READING
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