DNA dynamics in a microchannel.

  title={DNA dynamics in a microchannel.},
  author={Richard Martin Jendrejack and E. Dimalanta and David C. Schwartz and Michael D. Graham and Juan J de Pablo},
  journal={Physical review letters},
  volume={91 3},
An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in… CONTINUE READING