DNA-drug interactions. The crystal structure of d(CGATCG) complexed with daunomycin.

@article{Moore1989DNAdrugIT,
  title={DNA-drug interactions. The crystal structure of d(CGATCG) complexed with daunomycin.},
  author={M J Moore and William N. Hunter and B{\'e}atrice Langlois d'Estaintot and Olga Kennard},
  journal={Journal of molecular biology},
  year={1989},
  volume={206 4},
  pages={693-705}
}
The structure of a d(CGATCG)-daunomycin complex has been determined by single crystal X-ray diffraction techniques. Refinement, with the location of 40 solvent molecules, using data up to 1.5 A, converged with a final crystallographic residual, R = 0.25 (RW = 0.22). The tetragonal crystals are in space group P4(1)2(1)2, with cell dimensions of a = 27.98 A and c = 52.87 A. The self-complementary d(CGATCG) forms a distorted right-handed helix with a daunomycin molecule intercalated at each d(CpG… CONTINUE READING