DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts

@article{Matsui2015DNADB,
  title={DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts},
  author={Yuki Matsui and Yumi Sunatani and Norifumi Hayashi and Kazuaki Okino and Yuki Okushi and Kiyotaka Mukai and Hiroki Adachi and Hideki Yamaya and Kuniyoshi Iwabuchi and Hitoshi Yokoyama},
  journal={Clinical and Experimental Nephrology},
  year={2015},
  volume={20},
  pages={479-488}
}
The relationship between DNA damage and glomerular fibrosis in renal allografts remains unclear. We examined renal allograft specimens from 35 patients in which DNA double-strand breaks (DSBs) and glomerular fibrosis were detected by phospho-histone H2A.X (γ-H2AX) expression and collagen (COL) types III, IV, and VI accumulation. We also examined the in… CONTINUE READING