DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?

@article{Msiska2010DNADB,
  title={DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?},
  author={Zola Msiska and Maricica Pacurari and Anurag R Mishra and Stephen S. Leonard and Vincent Castranova and Val Vallyathan},
  journal={American journal of respiratory cell and molecular biology},
  year={2010},
  volume={43 2},
  pages={210-9}
}
DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One of the earliest responses to DNA DSBs is the phosphorylation of a histone, H2AX, at serine 139 (gamma-H2AX), which can be detected by a fluorescent antibody. A study was undertaken… CONTINUE READING
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