DNA double-strand breaks: signaling, repair and the cancer connection

@article{Khanna2001DNADB,
  title={DNA double-strand breaks: signaling, repair and the cancer connection},
  author={Kum Kum Khanna and Stephen P. Jackson},
  journal={Nature Genetics},
  year={2001},
  volume={27},
  pages={247-254}
}
To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a complex DNA-damage-response pathway that includes cell-cycle arrest, the transcriptional and post-transcriptional activation of a subset of genes including those associated with DNA repair, and, under some circumstances, the triggering of programmed cell death. An inability to respond properly to, or to repair, DNA damage leads… 
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