DNA double-strand breaks, potential targets for HBV integration

  title={DNA double-strand breaks, potential targets for HBV integration},
  author={Xiaowen Hu 胡晓文 and Jusheng Lin 林菊生 and Qionghui Xie 谢琼慧 and Jinghua Ren 任精华 and 莹 YingChang常 and Wenjie Wu 吴文杰 and Yujia Xia 夏羽佳},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers. Hepadnaviral DNA integrations are considered to be essential agents which can promote the process of the hepatocarcinogenesis. More and more researches were designed to find the relationship of the two. In this study, we investigated whether HBV DNA integration occurred at sites of DNA double-strand breaks (DSBs), one of the most detrimental DNA damage. An 18-bp I-SceI homing… CONTINUE READING


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