DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.


MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design with a focused chemical library to discover… (More)
DOI: 10.1016/j.molcel.2013.11.003


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