DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis.

@article{Inagaki2010DNADS,
  title={DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis.},
  author={Akiko Inagaki and Sam Schoenmakers and Willy M Baarends},
  journal={Epigenetics},
  year={2010},
  volume={5 4},
  pages={255-66}
}
Chromosome pairing and synapsis during meiotic prophase requires the formation and repair of DNA double-strand breaks (DSBs) by the topoisomerase-like enzyme SPO11. Chromosomes, or chromosomal regions, that lack a pairing partner, such as the largely heterologous X and Y chromosomes, show delayed meiotic DSB repair and are transcriptionally silenced. Herein, we review meiosis-specific aspects of DSB repair in relation to homology recognition and meiotic silencing of heterologous regions. We… CONTINUE READING