DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

Abstract

PURPOSE del(17p), del(11q), and associated p53 dysfunction predict for short survival and chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA-dependent protein kinase (DNA-PK) is activated by DNA damage and mediates DNA double-strand break repair. We hypothesized that inhibiting DNA-PK would sensitize CLL cells to drug-induced DNA damage and… (More)
DOI: 10.1158/1078-0432.CCR-07-5158

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Cite this paper

@article{Willmore2008DNAdependentPK, title={DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.}, author={Elaine G Willmore and Sarah L. Elliott and Tryfonia Mainou-Fowler and Geoffrey P Summerfield and Graham Hunter Jackson and Fran O'Neill and Christopher Robin Lowe and Anthony P. Carter and Robert Harris and Andrew R. Pettitt and Celine Cano-Soumillac and Roger J. Griffin and Ian G. Cowell and Caroline Ann Austin and Barbara W. Durkacz}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2008}, volume={14 12}, pages={3984-92} }