DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.

@article{Jack2004DNAdependentPK,
  title={DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.},
  author={Melissa T Jack and Richard A. Woo and Noboru Motoyama and Hitoyuki Takai and Patrick W.K. Lee},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={15269-73}
}
The role of the checkpoint kinase 2 (Chk2) as an upstream activator of p53 following DNA damage has been controversial. We have recently shown that Chk2 and the DNA-dependent protein kinase (DNA-PK) are both involved in DNA damage-induced apoptosis but not G(1) arrest in mouse embryo fibroblasts. Here we demonstrate that Chk2 is required to activate p53 in vitro as measured by its ability to bind its consensus DNA target sequence following DNA damage and is in fact the previously unidentified… CONTINUE READING

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