DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

@article{Woo1998DNAdependentPK,
  title={DNA-dependent protein kinase acts upstream of p53 in response to DNA damage},
  author={Richard A. Woo and Kevin G. McLure and Susan P Lees-Miller and D. E. Rancourt and Patrick W. K. Lee},
  journal={Nature},
  year={1998},
  volume={394},
  pages={700-704}
}
The tumour suppressor p53 becomes activated as a transcription factor in response to DNA damage, but the mechanism for this activation is unclear. A good candidate for an upstream activator of p53 is the DNA-dependent protein kinase (DNA-PK) that depends on the presence of DNA breaks for its activity. Here we investigate the link between DNA damage and the activation of DNA-PK and of p53. To determine whether DNA-PK is an upstream mediator of the p53 DNA-damage response, we analysed a severe… CONTINUE READING

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