DNA-dependent formation of transcription factor pairs alters their binding specificity

@article{Jolma2015DNAdependentFO,
  title={DNA-dependent formation of transcription factor pairs alters their binding specificity},
  author={Arttu Jolma and Yimeng Yin and Kazuhiro R. Nitta and Kashyap Dave and Alexander Popov and Minna Taipale and Martin Enge and Teemu Kivioja and Ekaterina Morgunova and Jussi Taipale},
  journal={Nature},
  year={2015},
  volume={527},
  pages={384-388}
}
Gene expression is regulated by transcription factors (TFs), proteins that recognize short DNA sequence motifs. Such sequences are very common in the human genome, and an important determinant of the specificity of gene expression is the cooperative binding of multiple TFs to closely located motifs. However, interactions between DNA-bound TFs have not been systematically characterized. To identify TF pairs that bind cooperatively to DNA, and to characterize their spacing and orientation… CONTINUE READING