DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway.

@article{Zhang2013DNAdependentAO,
  title={DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway.},
  author={Weijuan Zhang and Qian Zhou and Wei Xu and Yanxing Cai and Zhinan Yin and Xiao-ming Gao and Sidong Xiong},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 19},
  pages={13534-50}
}
BACKGROUND Macrophage M2b polarization conferred by self-DNA immunization initiates and propagates lupus nephritis. RESULTS Knockdown of DNA-dependent activator of interferon-regulatory factors (DAI) ameliorates SLE syndrome via blunting macrophage M2b polarization. CONCLUSION DAI functions as a DNA sensor in self-DNA-induced macrophage M2b polarization and lupus nephritis. SIGNIFICANCE We disclose the mechanism by which self-DNA induces macrophage M2b polarization and lupus nephritis DNA… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Immune sensing of nucleic acids in inflammatory skin diseases

Seminars in Immunopathology • 2014
View 7 Excerpts
Highly Influenced

Regulating STING in health and disease

Journal of Inflammation • 2017
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…