DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

@article{Baron2007DNADI,
  title={DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.},
  author={Udo Baron and Stefan Floess and Georg Wieczorek and Katrin Baumann and Andreas Gr{\"u}tzkau and Jun Dong and Andreas Thiel and Tina J Boeld and Petra Hoffmann and Matthias Edinger and Ivana Tuerbachova and Alf Hamann and Sven Olek and Jochen Huehn},
  journal={European journal of immunology},
  year={2007},
  volume={37 9},
  pages={2378-89}
}
The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg). Their number and functioning appears to be crucial in the prevention of autoimmunity and allergy, but also to be a negative prognostic marker for various solid tumors. Although expression of the transcription factor FOXP3 currently constitutes the best-known marker for Treg, in humans, transient expression is also observed in activated non-Treg. Extending our recent findings for the murine… CONTINUE READING
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