DNA demethylation facilitates the specific transcription of the mouse X-linked Tsga8 gene in round spermatids†.

@article{Lu2019DNADF,
  title={DNA demethylation facilitates the specific transcription of the mouse X-linked Tsga8 gene in round spermatids†.},
  author={Yongjie Lu and Shunyao Liao and Wenling Tu and Bo Yang and Shasha Liu and Xue Pei and Da-chang Tao and Yi-lu Lu and Yongxin Ma and Yuan Yang and Yunqiang Liu},
  journal={Biology of reproduction},
  year={2019},
  volume={100 4},
  pages={
          994-1007
        }
}
Some X-linked genes necessary for spermiogenesis are specifically activated in the postmeiotic germ cells. However, the regulatory mechanism about this activation is not clearly understood. Here, we examined the potential mechanism controlling the transcriptional activation of the mouse testis specific gene A8 (Tsga8) gene in round spermatids. We observed that the Tsga8 expression was negatively correlated with the methylation level of the CpG sites in its core promoter. During spermatogenesis… 
1 Citations
Tsga8 is required for spermatid morphogenesis and male fertility in mice.
TLDR
It is shown that one of the genes targeted by KMT2B, Tsga8, plays an essential role in spermatid morphogenesis and is a K MT2B target that is vitally necessary for spermiogenesis and fertility.

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