DNA demethylation: turning genes on.

  title={DNA demethylation: turning genes on.},
  author={Yehudit Bergman and Ra{\'u}l Mostoslavsky},
  journal={Biological chemistry},
  volume={379 4-5},
The regulation of eukaryotic gene expression is a complicated process involving the interaction of a large number of transacting factors with specific cis-regulatory elements. DNA methylation plays a role in this scheme by acting in cis to modulate protein-DNA interactions. Several lines of evidence indicate that methylation serves to silence transcription, mainly through indirect mechanisms involving the assembly of repressive nucleoprotein complexes. DNA demethylation is mostly an active… CONTINUE READING

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