DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma

@inproceedings{Amodio2012DNAdemethylatingAA,
  title={DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple
myeloma},
  author={Nicola Amodio and Marzia Leotta and Dina Bellizzi and Maria Teresa Di Martino and Patrizia D'Aquila and Marta Lionetti and Fernanda Fabiani and Emanuela Leone and Anna Maria Gull{\`a} and Giuseppe Passarino and Michele Caraglia and Massimo Negrini and Antonino Neri and Antonio Giordano and Pierosandro Tagliaferri and Pierfrancesco Tassone},
  booktitle={Oncotarget},
  year={2012}
}
Aberrant DNA methylation plays a relevant role in multiple myeloma (MM) pathogenesis. MicroRNAs (miRNAs) are a class of small non-coding RNAs that recently emerged as master regulator of gene expression by targeting protein-coding mRNAs. However, miRNAs involvement in the regulation of the epigenetic machinery and their potential use as therapeutics in MM remain to be investigated. Here, we provide evidence that the expression of de novo DNA methyltransferases (DNMTs) is deregulated in MM cells… CONTINUE READING