DNA delivery from polymer matrices for tissue engineering

@article{Shea1999DNADF,
  title={DNA delivery from polymer matrices for tissue engineering},
  author={Lonnie D Shea and Elizabeth C Smiley and Jeffrey Bonadio and David J Mooney},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={551-554}
}
We have proposed engineering tissues by the incorporation and sustained release of plasmids encoding tissue-inductive proteins from polymer matrices. Matrices of poly(lactide-co-glycolide) (PLG) were loaded with plasmid, which was subsequently released over a period ranging from days to a month in vitro. Sustained delivery of plasmid DNA from matrices led to the transfection of large numbers of cells. Furthermore, in vivo delivery of a plasmid encoding platelet-derived growth factor enhanced… CONTINUE READING
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