DNA-damaging natural products with potential anticancer activity

@article{Gunatilaka1997DNAdamagingNP,
  title={DNA-damaging natural products with potential anticancer activity},
  author={A. Gunatilaka and D. G. Kingston},
  journal={Studies in natural products chemistry},
  year={1997},
  volume={20},
  pages={457-505}
}
  • A. Gunatilaka, D. G. Kingston
  • Published 1997
  • Biology
  • Studies in natural products chemistry
  • Publisher Summary This chapter demonstrates the utility of the yeast bioassay for the detection and isolation of DNA-damaging agents in plant and marine extracts. The assay has many advantages: it is relatively easy to set up and maintain and it is economical to run because no expensive reagents or radioisotopes are required. Because it is a mechanism-based assay, those compounds isolated through its use have a mechanism of action that is at least partially understood, and thus can proceed more… CONTINUE READING
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